International Genetics of Ankylosing Spondylitis Consortium Conference 2023

Include: 5 videos + 5 file sub vtt + 1 pdf, size: 50.77 GB
Target Audience: rheumatologists, geneticists & immunologists
Information:

IGAS 2023: THE GENETIC FRONTIER OF SPONDYLOARTHRITIS

“From GWAS to Function: Decoding the Ankylosing Spondylitis Genome”

🗓️ Conference Dates: March 30 – April 1, 2023

📍 Location: Naples, Italy (Centro Congressi Federico II)

Academic Host: The International Genetics of Ankylosing Spondylitis (IGAS) Consortium

ℹ️ General Information

Welcome to the premier gathering of the global Spondyloarthritis (SpA) research community. The IGAS 2023 Conference represents a critical turning point in rheumatology: the shift from simply identifying risk genes to understanding their function in the immune system.

Held in the historic academic center of Naples, this exclusive summit brings together the world’s leading geneticists and immunologists. Unlike general rheumatology meetings, IGAS focuses entirely on the molecular engine driving Axial Spondyloarthritis. This course offers a deep dive into how the “Dark Matter” of the genome interacts with the microbiome to trigger inflammation.

• Format: High-Level Scientific Plenary + Interactive “Young Investigator” Sessions.

• Focus: Translational Medicine (Genetics, Pathogenesis, New Therapies).

• Language: English.

👥 Target Audience

This advanced curriculum is designed for medical professionals and researchers operating at the cutting edge of immunology:

1. Academic Rheumatologists: Who need to understand the “Polygenic Risk Scores” that will soon guide prognosis in clinical practice.

2. Geneticists & Immunologists: Investigating the functional consequences of HLA-B27 and ERAP1 interaction.

3. Pharma & Biotech Researchers: Looking for the next generation of therapeutic targets beyond TNF and IL-17 inhibitors.

🎯 Learning Objectives

By analyzing the 2023 consortium data, participants will be able to:

1. Interpret Polygenic Risk Scores (PRS): Understand how cumulative genetic risk is calculated and its potential to predict disease severity in axSpA.

2. Connect Gut & Spine: Explain the causal relationship between the gut microbiome and entheseal immunity using Mendelian Randomization techniques.

3. Target the Misfolding: Evaluate the role of ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) and its potential as a drug target.

4. Analyze Rare Variants: Differentiate between common GWAS hits and rare, high-impact variants found in multi-case families.

📚 Conference Topics & Modules

*Note: these are continuous video recordings during the conference, they include individual lectures mentioned in the below

DAY 1 – 30th March 2023

08:30 AM – DAY 1 – 30th March 2023

8:30 – 8:45 8.30 – 9:00

Registration CME Welcome

09:00 AM – DAY 1 – 30th March 2023 – Session 1 Genetic – Chair: Paul Wordsworth, Matthew Brown

9:00 – 9:20	Overview on genetic in axSpA	Matthew Brown
9:20 – 9:40	Polygenic risk score in biomedical research	Richard Oram
9:40 – 10:00	Polygenic risk scores in axSpA	Huji Xu
10:00 – 10:20	Functional evaluation of ERAP1 in axSpA	Tony Kenna
10:20 – 10:40	Questions and Discussion (Regarding the subject included in the session)	interactive

10:40 AM – Day 1 – 30th March 2023 – Coffee Break

from 10:40 to 11:00

11:00 AM – DAY 1 – 30th March 2023 – Session 2 Genetic – Chair: Maxime Breban, Carlo F. Selmi

11:00 – 11:20	Exploring rare variants in multicase Families	Felicie Costantino
11:20 – 11:40	News from B27 transgenic drosophila	Vincent Rincheval
11:40 – 12:00	Functional genomics in axSpA	Matteo Vecellio
12:00 – 12:15	Questions and Discussion (Regarding the subject included in the session)	Interactive

12:15 PM – DAY 1 – 30th March 2023 – Young Session – Chair: Matthew Brown

12:15 – 12:25	Validating the arthritogenic hypothesis: connections between gut and entheseal immunity	Jose Garrido Mesa
12:25 – 12:35	Identifying causal relationships between gut microbiome and axSpA through mendelian randomization	Nicholas Harvey
12:35 – 12:45	Exploring TLR signaling in DC from HLA-B27 transgenic rat	Ait Ali Said Amel
12:45 – 1:00	Discussion (Regarding the subject included in the session)

01:00 PM – DAY 1 – 30th March 2023 – Lunch

from 1:00 PM to 2:00 PM

02:00 PM – DAY 1 – Session 3 – Microbiome – Chair: Huji Xu, Torkell Ellingsen

2.00 – 2:20	Microbiome and axSpA pathogenesis	Maxime Breban
2:20 – 2:40	The role of gut bacteria in the development of Spondyloarthritis	Anne Sophie Bergot
2:40 – 3:00	Fecal microbial transplantation in axSpA	Maja Kragsnæs
3:00 – 3:20	Questions and Discussion (Regarding the subject included in the session)	Interactive

03:20 PM – DAY 1 – Coffee Break

From 3:20 PM to 3:40 PM

03:40 PM – DAY 1 – 30th March 2023 – Session 4 The Mucosal Corner – Chair: Giuliana Guggino, Rosario Peluso

3:40 – 4:00	Gut and axSpA: evidence and controversies	Francesco Ciccia
4.00 – 4:20	News from the gut in axSpA	Thomas Bazin
4:20 – 4:40	Modulation of epithelial intestinal barrier in the pathogenesis of inflammatory arthritis	Aline Bozec
4:40 -5:00	New mucosal player in axSpA pathogenesis	Daniele Mauro
5:00 – 5:20	Questions and Discussion (Regarding the subject included in the session)	Interactive

DAY 2 – 31st March 2023

08:50 AM – DAY 2 – 31st March 2023 – Session 5 – Adaptive Immunity – Chair: Robert D. Inman, Nigil Haroon

8.50 – 09:10	Co-receptors in helper and cytotoxic T cells function	Ondrej Stepanek
09:10 – 09:30	DCs and Th17 interaction in B27 transgenic rat	Simon Glatigny
09:30 – 09:50	Single cell insights into the immunology of axSpA	Davide Simone
09:50 – 10:10	Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides	Paul Bowness
10:10 – 10:30	Questions and Discussion (Regarding the subject included in the session)	interactive

10:30 AM – DAY 2 – 31st March 2023 – Coffee Break

From 10:30 AM to 10:50 AM

10:50 AM – Day 2 – 31st March 2023 – Session 6 – Adaptive Immunity – Chair: Paul Bowness, Roberto Giacomelli

10:50 – 11:10	TCR immunology	Jia Jia Lim
11:10 – 11:30	Interleukin 17 inhibitors and the effect on enthesitis and pain in Spondyloarthritis	Marije Koenders
11.30 – 11.50	Immunopathogenesis of enthesistis in axSpA	Dennis Mc Gonagle
11.50 – 12.10	Questions and Discussion (Regarding the subject included in the session)

12:10 PM – DAY 2 – 31st March 2023 – Lunch

from 12:10 PM to 1:30 PM

01:30 PM – DAY 2 – Session 7 – Innate Immunity – Chair: Irene van der Horst-Bruinsma, Dirk Elewaut

1:30 – 1:50	MIF: a potential therapeutic target in axSpA	Nigil Haroon
1:50 – 2:10	Dysregulated CTL Exhaustion in axSpA	Michael Tang
2:10 – 2:30	ZRANB1 in AS pathogenesis	Archita Shrinath
2:30 – 3:00	Questions and Discussion (Regarding the subject included in the session)	Interactive

03:00 PM – DAY 2 – 31st March 2023 – Coffee Break

From 3:00 PM to 3:20 PM

03:20 PM – DAY 2 – 31st March 2023 – Session 8 – Innate Immunity – Chair: Alberto Cauli, Carlomaurizio Montecucco

3:20 – 3:40	Immune tolerance and resolution of inflammation in inflammatory arthritis	Stefano Alivernini
3:40 – 4:00	Metabolic control of Innate lymphoid cells	Chen Dong
4:00 – 4:20	Questions and Discussion (Regarding the subject included in the session)	Interactive

04:20 PM – DAY 3 – 31st March 2023 – Young Session – Chair: Roberto Giacomelli, John Reveille

4:20 – 4:30	Profiling T cell receptor polymorphisms in axSpA	Zoya Qaiyum
4:30 – 4:40	Leaky gut in SpA: focus on ZEB proteins	Chiara Rizzo
4:40 – 4:50	How does TGFb affect CD4+ T cell response in axSpA?	Marc Lauraine
4:50 – 5:05	Discussion (Regarding the subject included in the session)

05:05 PM – DAY 2 – 31st March 2023 – Lecture not included in the educational program CME

5:05 – 5:25	The lecture has not been included in the educational program CME From patient side: the role of Ixekizumab in patient reported outcomes	Ennio Favalli
5:25 – 5:45	The lecture has not been included in the educational program CME The recognition and management of early PsA: which role for the IL23 inhibitor GuselKumab?	Ilenia Pantano

DAY 3 – 1st April 2023

08:30 AM – DAY 3 – 1st April 2023 – Session 9 – Osteoimmunology – Chair: Lianne Genssler, Georg Schett

8:30 – 8:50	Immune-stromal interaction in bone formation	Nicole Horwood
8:50 – 9:10	Mechano-inflammation in axSpA	Dirk Elewaut
9:10 – 9:30	Fibroblast Activation Protein (FAP) PET-CT for depicting osteoproliferation in axSpA patient	Andreas Ramming
9:30 – 9:50	Questions and Discussion (Regarding the subject included in the session)	interactive

09:50 AM – DAY 3 – 1st April 2023 – Session 10 – Clinical Overview 1 – Chair: Paul Bowness, AnnaMaria Iagnocco

9:50 – 10:10	Sex-specific differences in axSpA: myth or truth?	Irene Van der Host-Bruinsma
10:10 – 10:30	Sex differences in treatment efficacy of interleukin 17 inhibitors in Spondyloarthritis	Emmerik Leijten
10:30 – 10:50	Insight in PsA by imaging	AGeorg Schett
10:50 – 11:00	Questions and Discussion (Regarding the subject included in the session)	interactive

11:10 AM – DAY 3 – 1st April 2023 – Session 11 – Clinical Overview 2 – Chair: Felicie Costantino, Raffaele Scarpa

11:10 – 11:30	Biomarkers predictive of clinical response in AxSpA	John Reveille
11:30 – 11:50	ASAS-Eular recommendations for the management of AxSpA	Lianne Gensler
11.50 – 1 2.10	The added value of sonography in SpA diagnosis and monitoring	Maria Antonietta D’Agostino
12:10 – 12.30	Questions and Discussion (Regarding the subject included in the session)	Interactive

12:30 PM – DAY 3 – 1st April 2023 – Young Session – Chair: Luisa Costa

12:30 – 12:40	Comorbidities and metabolic burdern in early PSA: data from prospective metapsa cohort	Alla Ishchenko
12:40 – 12:50	Cytof profiling of blood populations in axSpA”	Claudia Worth
12:50 – 1:00	IL-24 as biomarkers in axSpA	Giulio Forte
1:00 – 1:15	Discussion (Regarding the subject included in the session)

01:15 PM – DAY 3 – 1st April 2023 – Mark Asquith Award

1:15- 1:25

“Mark Asquith” award for best young presentation